Iron Accumulation in C.elegans: A Model of Ageing

Grant number: DP130100357 | Funding period: 2013 - 2016

Completed

Abstract

This project will investigate the role of biological metals in the process of ageing, the causes of which remain unresolved. The practical outcomes for society are broad; beyond improving understandings of the basic biology of ageing, this study will provide new insight and approaches that can be used to optimise lifespan.

Related publications (5)

φxANES: In vivo imaging of metal-protein coordination environments

SA James, DJ Hare, NL Jenkins, MD De Jonge, AI Bush, G McColl

2016-02-10

We have developed an X-ray absorption near edge structure spectroscopy method using fluorescence detection for visualizing in vivo..

High-resolution complementary chemical imaging of bio-elements in Caenorhabditis elegans

DJ Hare, MWM Jones, VC Wimmer, NL Jenkins, MD De Jonge, AI Bush, G McColl

2016-02-01

Here, we present a sub-μm multimodal approach to image essential elements in Caenorhabditis elegans. A combination of chemical ima..

Direct in vivo imaging of ferrous iron dyshomeostasis in ageing Caenorhabditis elegans

SA James, BR Roberts, DJ Hare, MD De Jonge, IE Birchall, NL Jenkins, RA Cherny, AI Bush, G McColl

2015-05-01

Iron is essential for eukaryotic biochemistry. Systematic trafficking and storage is required to maintain supply of iron while pre..

Biological metals and metal-targeting compounds in major neurodegenerative diseases

KJ Barnham, AI Bush

2014-01-01

Multiple abnormalities occur in the homeostasis of essential endogenous brain biometals in age-related neurodegenerative disorders..

Direct in vivo imaging of essential bioinorganics in Caenorhabditis elegans

SA James, MD De Jonge, DL Howard, AI Bush, D Paterson, G McColl

2013-06-01

Metals are essential in biochemistry, with highly regulated localisation and concentration. To continue elucidating the impact of ..

University of Melbourne Researchers

Ashley Bush

Gawain McColl